En studie til som nevner at økt CO2 i blodet (hypercapni) virker beskyttende fordi det demper betennelser, spesielt betennelsesfaktoren IL-8.

I denen Studien er pH helt nede på 7,0 og CO2 oppe i 75mmHg.

http://www.atsjournals.org/doi/full/10.1165/rcmb.2002-0126OC#.Un3l55Ez448

Although the protective effects of the hypoventilation technique for treating ARDS patients have been considered to be the consequence of a low tidal volume decreasing excessive mechanical stretch of lung tissue (4, 5), the findings of the present study indicate that the benefits are provided not only by decreased stretch, but also by coexisting hypercapnic acidosis having anti-inflammatory effects. These facts suggest that the protective effects of the hypoventilation technique during treatment of ARDS patients may be enhanced when coexisting hypercapnic acidosis is not corrected either by increasing respiratory frequency or by adding sodium bicarbonate.