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Melatonin induces γ- glutamylcysteine syn thetase mediated by activator protein-1 in human vascular en dothelial cells

Det første bildet viser hvordan melatonin dobler glutathion konsentrasjon. Dette er interessant med tanke på at diafragmiske pust øker melatonin. Melatonin hemmer enzymet som bryter ned glutathion, derfor økes konsentrasjonen.

http://www.sciencedirect.com/science/article/pii/S0891584999001318

In the present study, we show that melatonin induces the expression of γ-glutamylcysteine synthetase (γ-GCS), the rate-limiting enzyme of glutathione (GSH) synthesis, in ECV304 human vascular endothelial cells.

As conclusion, induction of GSH synthesis by melatonin protects cells against oxidative stress and regulates cell proliferation.

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