MSM sitt forhold til homocystein

Homocystein er sett på som utgangspunktet for mange livsstilssykdommer. Homocystein økes av det moderne kostholdet med mye kjøtt spesielt.

Denn studien nevner at MSM reduserer homocystein-økning etter trening.

Aside from measures of antioxidant status (TEAC and glutathione), we included the measure of homocysteine in the current design. Homocysteine is a non-protein amino acid, with elevated levels in circulation thought to be associated with an increased risk of cardiovascular disease; although recent evidence questions this association [22]. A study by Kim et al. reported a statistically significant lowering of homocysteine (8.0 to 7.2 μmol·L-1) in a sample of knee osteoarthritis patients following intake of MSM at a dosage of 6 grams per day for 12 weeks [4]. Data from the present investigation somewhat corroborate the work of Kim and colleagues, as we noted a lowering of homocysteine during the post-exercise period after subjects were supplemented with MSM for four weeks (Figure (Figure3).3). The mechanism of action of this effect may be linked to methyl group donation by MSM, in much the same way as done by B-vitamins [23].

Og denne nevner at homocystein har en direkte giftig effekt på sirkulasjonssystemet og nervesystemt og er assosiert med mange nevrologiske sykdommer.

Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism. It has a physiologic role in DNA metabolism via methylation, a process governed by the presentation of folate, and vitamins B6 and B12. Physiologic Hcy levels are determined primarily by dietary intake and vitamin status. Elevated plasma levels of Hcy (eHcy) can be caused by deficiency of either vitamin B12 or folate, or a combination thereof. Certain genetic factors also cause eHcy, such as C667T substitution of the gene encoding methylenetetrahydrofolate reductase. eHcy has been observed in several medical conditions, such as cardiovascular disorders, atherosclerosis, myocardial infarction, stroke, minimal cognitive impairment, dementia, Parkinson’s disease, multiple sclerosis, epilepsy, and eclampsia. There is evidence from laboratory and clinical studies that Hcy, and especially eHcy, exerts direct toxic effects on both the vascular and nervous systems. This article provides a review of the current literature on the possible roles of eHcy relevant to various neurologic disorders.

Studien nevner at homocystin transformeres tilbake til methionin ved hjelp av B12, med hjelp av folat og B6 (svovel-holdig b-vitamin). Som den første studien viser vil også MSM virke direkte reduserende på homocystein og dermed kan vi forklare den smerte- og symptomreduserende effekten MSM har på nevrologiske problemer.