Multipotential Mesenchymal Stem Cells Are Mobilized into Peripheral Blood by Hypoxia

Nevner at ved 50% mindre oksygen så kommer en type stamceller ut, MSC, som kan bli skjelett, blodkar og fettceller. Men å få 50% mindre oksygen ved pusteteknikker er svært vanskelig. Ved 4000 moh kan vi få det til om vi er der lenger enn 3 uker, slik som musene i denne studien.

«Hypoxia-induced mobilization appears to be specific for MSCs since total circulating hematopoietic progenitor cells were not significantly increased»

«Certain stem cells are able to exit their production site, circulating into blood before reseeding their target tissues. In the case of hematopoietic stem cells (HSCs), such circulation is essential during development since they migrate from one site to the next (embryonic aorta-gonad-mesonephros region, fetal liver, adult bone marrow).»

«Adult male Wistar rats (7 weeks, 220 g; Harlan, Gannat, France, were housed for 3 weeks in a hypoxic chamber (50 kPa), which caused chronic hypoxia, as previously described [27], and were compared with matched control rats housed in normoxic conditions (101 kPa). «

Viser hvor mye stamceller som er i blod (PBH) i hypoxi (50 kPa) relativt til normoxi (PBN – 101 kPa)

«In conclusion, we report that few MSCs circulate in the PB under stationary conditions in rats. Large amounts of MSCs can be mobilized (an increase of almost 15-fold) under hypoxic conditions. These data demonstrate that MSCs can be mobilized into the PB via stimuli distinct from those involved in hematopoietic stem cell mobilization.»

Hypoxia: Are stem cells in it for the long run?

Om stamceller og at hypoxi og HIF-a er viktig for deres overlevelse og funksjon.

«tudies by others over the past 10 years has also indicated that hypoxia and Hif expression are essential for self-renewal and are involved in the regulation of proliferation for some types of stem cells. «