The gluten syndrome: A neurological disease

Nevner det meste om gluten relatert til nerveproblemer. Noe av årsaken ligger i at det blir en autoimmun plage med antistoffer i nerver, som etter hvert gir nerveskader. 64% av de med cøliaki har også nevropati.

Hypothesis: Gluten causes symptoms, in both celiac disease and non-celiac gluten-sensitivity, by its adverse actions on the nervous system.
Many celiac patients experience neurological symptoms, frequently associated with malfunction of the autonomic nervous system. These neurological symptoms can present in celiac patients who are well nourished. The crucial point, however, is that gluten-sensitivity can also be associated with neurological symptoms in patients who do not have any mucosal gut damage (that is, without celiac disease).
Gluten can cause neurological harm through a combination of cross reacting antibodies, immune com- plex disease and direct toxicity. These nervous system affects include: dysregulation of the autonomic nervous system, cerebella ataxia, hypotonia, developmental delay, learning disorders, depression, migraine, and headache.
If gluten is the putative harmful agent, then there is no requirement to invoke gut damage and nutri- tional deficiency to explain the myriad of the symptoms experienced by sufferers of celiac disease and gluten-sensitivity. This is called ‘‘The Gluten Syndrome”.

A mechanism for such nerve damage might be through autoimmune damage [15]. A number of nerve and brain antibodies have been detected. Anti-ganglioside antibodies have been detected in 64% of patients with celiac disease who had also been troubled with some sort of neuropathy [16]. These auto-antibodies have been shown to bind to a number of critical nerve sites that will go on to damage the nerve.

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