Om hvordan small fiber neuropathy (prikking, stikking, brenning, nummenhet, osv) kommer av redusert antall c-fibere i huden, og dermed ferre signaler opp til hjernen. Kan hjernen reagerer på lavt antall c-fibere med å sende smerte ut?

http://www.ncbi.nlm.nih.gov/m/pubmed/23399897

Assessment of intraepidermal nerve fiber density (IENFD) has become a useful tool for the investigation of patients with suspected small-fiber neuropathy (SFN).

Mean IENFD in SFN patients was 2.22 ± 1.63 mm versus 7.51 ± 2.17 mm in controls; mean length density was 112 ± 82.6 mm in SFN patients versus 565 ± 240 mm in controls (p < 0.001 for both).

There were significant differences in axonal swelling ratios between healthy subjects and patients, that is, per IENFD and per nerve fiber length