Om at kramper kan ha grunnlag i small fiber neuropathy. Nevropatien øker betennelsesutskillelsen fra nervecellene som dermed øker muskelsammentreningssignalene.

http://www.ncbi.nlm.nih.gov/m/pubmed/23813593/

Introduction: Muscle cramps are a common complaint and are thought to arise from spontaneous discharges of the motor nerve terminal.

Conclusions: Our data show that 60% of patients with muscle cramps who lack neuropathic complaints have SFN, as documented by decreased IENFD. Cramps may originate as local mediators of inflammation released by damaged small nerve that excite intramuscular nerves.