Inflammation in complex regional pain syndrome A systematic review and meta-analysis

Studie som viser at betennelser er et viktig aspekt av CRPS (kompleks smertesyndrom). Og den nevner det viktige prinsippet om at betennelsesfaktorer er like fremtredene i den smertefrie siden. Dette kan også gjelde ved andre betennelsestilstander….

» CRPS is associated with the presence of a proinflammatory state in the blood, blister fluid, and CSF. Different inflammatory profiles were found for acute and chronic cases»

«In acute CRPS, the concentrations of interleukin (IL)-8 and soluble tumor necrosis factor receptors I (sTNF-RI) and II (sTNF-RII) were significantly increased in blood.
In chronic CRPS, significant increases were found in 1) TNFα, bradykinin, sIL-1RI, IL-1Ra, IL-2, sIL-2Ra, IL-4, IL-7, interferon-γ, monocyte chemoattractant protein-1 (MCP-1), and sRAGE (soluble receptor for advanced glycation end products) in blood; 2) IL-1Ra, MCP-1, MIP-1β, and IL-6 in blister fluid; and 3) IL-1β and IL-6 in CSF. »

«Inflammatory factor concentrations in CSF were reported in 3 chronic CRPS studies comparing CRPS cases to predominantly hospital controls.26,,28 »

«Complex regional pain syndrome (CRPS) is characterized by severe pain, allodynia, hyperalgesia, and motor and autonomic signs and symptoms.1»


«We found that the inflammatory factor profile in chronic CRPS, shown in figures 3 to 5, suggests a proinflammatory drive. In particular, the presence of cytokines such as IL-1 and IL-6 in the CSF suggests that the highly proinflammatory Th17 mechanisms may be active. »

«Previous work has shown that chronic pain is associated with higher levels of proinflammatory37 and lower antiinflammatory activity.38»

«Finally, our study found little empirical support for the position that the CRPS-affected limb expresses higher inflammatory factors than the unaffected limb.»
«Importantly, those studies that performed these side-to-side comparisons concluded that the levels of inflammatory factors in blood are not significantly different between the affected and the unaffected limb in either acute or chronic CRPS.»

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