Vitamin D Deficiency: What a Pain It Is

Gjennomgang av d-vitamin mangler og hva det kan skape av problemer i kroppen. Nevner hva som er anbefalt mengde i blod, 30-50 ng/ml, og at man kan ta 50.000 IU 1x uka i 8 uke for å øke D-vit nivået..,%20Vit%20D,%202003.pdf

Vitamin D deficiency causes muscle weakness and muscle aches and pains in both children and adults. Glerup et al8 reported that 88% of Danish women of Arab descent who presented with muscle pains and weakness were se- verely vitamin D–deficient. Bischoff et al9 observed that adults with vitamin D deficiency have muscle weakness and are more likely to fall.

Heaney et al14 estimated that the body uses 3000 to 5000 IU/d of vitamin D. What does the body do with all that vitamin D? Most organs in the body, including the brain, heart, pancreas, skin, and immune system, recog- nize 1,25-dihydroxyvitamin D.2,7 Furthermore, many of these organs also have the capacity to make 1,25- dihydroxyvitamin D.2,7 Besides regulating calcium homeo- stasis, 1,25-dihydroxyvitamin D is a potent inhibitor of cellular growth, stimulator of insulin secretion, modulator of immune function, and inhibitor of renin production.2,7 These functions are likely responsible for the numerous epidemiological observations that people who live at higher latitudes and who are more prone to vitamin D deficiency are at increased risk of developing prostate, colon, breast, and other solid tumors15; autoimmune dis- eases including multiple sclerosis and type 1 diabetes; hy- pertension; and cardiovascular heart disease.2,7

A serum 25-hydroxyvitamin D level of at least 20 ng/mL is necessary to minimally satisfy the body’s vitamin D requirement.14,16 Maintenance of a serum 25-hydroxy- vitamin D level of 30 to 50 ng/mL is preferred.2,7,14,17 (50 ng/ml x 2,5 = 125 nmol/L)

Vitamin D deficiency can be treated easily by giving the patient an oral dose of 50,000 IU of vitamin D once a week for 8 weeks.16 Long-term prevention of vitamin D defi- ciency can be accomplished by giving 50,000 IU of vitamin D once or twice a month.

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